Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.29 (overall 0.20) | 0.29 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in bergmann glia | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 21 Parkinson's papers of 343 | 0.59 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2009
Sealed predictions
- FGF14 in dopamine neurons, braak+0.49 (p 0.183) → +0.53 (p 0.138)receipt 2014
Swarm cases
receipt 2014: FGF14 in dopamine neurons, braak
- power
- full sample +0.51 (p 0.030, n 18), 95% CI +0.06 to +0.79. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.51 (p 0.029, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.028, n 18). not the mix.
- skeptic
- leave-one-out range +0.45 to +0.74, sign flips 0; without severely affected donors +0.51 (p 0.030, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FGF14 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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