Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.49 (overall 0.32) | 0.49 |
| cell type Human Protein Atlas | cell type enriched outside the brain (neutrophils) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 471 | 0.82 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1115
Sealed predictions
- FCGR2A in dopamine neurons, braak+0.28 (p 0.458) → -0.28 (p 0.472)receipt 1121
Swarm cases
receipt 1121: FCGR2A in dopamine neurons, braak
- power
- full sample +0.01 (p 0.956, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.922, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.12, sign flips 7; without severely affected donors +0.01 (p 0.956, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FCGR2A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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