parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.47 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in retinal pigment epithelial cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 979	0.82
pathways Reactome	2 pathways; mostly energy	0.60

No case: the score is under the bar. Receipt 0297

receipt 0304: FADS2 in dopamine neurons, braak

power: full sample -0.37 (p 0.130, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.34 (p 0.161, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.42 (p 0.084, n 18). could be the mix.
skeptic: leave-one-out range -0.47 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.130, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FADS2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0303: FADS2 in astrocytes, braak

power: full sample -0.22 (p 0.384, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.26 (p 0.298, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.32 (p 0.194, n 18). could be the mix.
skeptic: leave-one-out range -0.31 to -0.12, sign flips 0; without severely affected donors -0.22 (p 0.384, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FADS2 in astrocytes.

case closed: nothing better to follow up.

loading the receipts