Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: redafamdastat, jnj-42165279, acetaminophen | 1.00 |
| trials ClinicalTrials.gov | 16 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 25 Parkinson's papers of 2,303 | 0.57 |
| pathways Reactome | 1 pathway; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 6801
Sealed predictions
- FAAH in dopamine neurons, braak-0.41 (p 0.272) → -0.53 (p 0.140)receipt 6809
Swarm cases
receipt 6809: FAAH in dopamine neurons, braak
- power
- full sample -0.51 (p 0.031, n 18), 95% CI -0.79 to -0.06. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.51 (p 0.031, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.56 (p 0.015, n 18). not the mix.
- skeptic
- leave-one-out range -0.67 to -0.43, sign flips 0; without severely affected donors -0.51 (p 0.031, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FAAH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts