Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: damoctocog alfa pegol, simoctocog alfa, efanesoctocog alfa +13 | 0.81 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 14 Parkinson's papers of 2,953 | 0.64 |
| pathways Reactome | 16 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 16111
Sealed predictions
- F8 in dopamine neurons, braak+0.10 (p 0.803) → +0.50 (p 0.172)receipt 16119
Swarm cases
receipt 16119: F8 in dopamine neurons, braak
- power
- full sample +0.25 (p 0.323, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.36 (p 0.140, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.40 (p 0.099, n 18). could be the mix.
- skeptic
- leave-one-out range +0.14 to +0.40, sign flips 0; without severely affected donors +0.25 (p 0.323, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for F8 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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