Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.24 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket: drotrecogin alfa (activated) | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 20 Parkinson's papers of 4,810 | 0.60 |
| pathways Reactome | 10 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 1753
Sealed predictions
- F5 in dopamine neurons, braak+0.39 (p 0.303) → +0.71 (p 0.032)receipt 1759
Swarm cases
receipt 1759: F5 in dopamine neurons, braak
- power
- full sample +0.33 (p 0.185, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.093, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.074, n 18). could be the mix.
- skeptic
- leave-one-out range +0.22 to +0.41, sign flips 0; without severely affected donors +0.33 (p 0.185, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for F5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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