parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in pituitary stem cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 474	0.85
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 10196

receipt 10204: EYA1 in dopamine neurons, braak

power: full sample +0.52 (p 0.027, n 18), 95% CI +0.07 to +0.79. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.51 (p 0.030, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.027, n 18). not the mix.
skeptic: leave-one-out range +0.46 to +0.64, sign flips 0; without severely affected donors +0.52 (p 0.027, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for EYA1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10203: EYA1 in astrocytes, braak

power: full sample +0.12 (p 0.633, n 18), 95% CI -0.37 to +0.56. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.13 (p 0.609, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.23 (p 0.351, n 18). could be the mix.
skeptic: leave-one-out range +0.03 to +0.22, sign flips 0; without severely affected donors +0.12 (p 0.633, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for EYA1 in astrocytes.

case closed: nothing better to follow up.

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