Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 318 | 0.74 |
| pathways Reactome | 1 pathway; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 3983
Sealed predictions
- ERN1 in dopamine neurons, braak-0.05 (p 0.907) → -0.34 (p 0.375)receipt 3990
Swarm cases
receipt 3990: ERN1 in dopamine neurons, braak
- power
- full sample -0.14 (p 0.579, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.14 (p 0.579, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.369, n 18). could be the mix.
- skeptic
- leave-one-out range -0.28 to -0.05, sign flips 0; without severely affected donors -0.14 (p 0.579, n 18). fragile.
- cell type
- strongest in microglia: -0.59 (p 0.0099, n 18) vs -0.14 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ERN1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ERN1 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.18 p 0.534 (needs p < 4.9e-4)
Receipts
loading the receipts