Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody: epoetin beta, epoetin delta, epoetin alfa +8 | 0.45 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 10 Parkinson's papers of 1,919 | 0.69 |
| pathways Reactome | 5 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 3176
Sealed predictions
- EPOR in dopamine neurons, braak+0.00 (p 1.000) → -0.08 (p 0.840)receipt 3183
Swarm cases
receipt 3183: EPOR in dopamine neurons, braak
- power
- full sample -0.04 (p 0.861, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.476, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.198, n 18). could be the mix.
- skeptic
- leave-one-out range -0.11 to +0.09, sign flips 4; without severely affected donors -0.04 (p 0.861, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for EPOR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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