Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in müller glia | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 16720
Sealed predictions
- EPHB6 in dopamine neurons, braak-0.12 (p 0.767) → -0.33 (p 0.389)receipt 16727
Swarm cases
receipt 16727: EPHB6 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.351, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.24 (p 0.341, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.030, n 18). not the mix.
- skeptic
- leave-one-out range -0.32 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.351, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for EPHB6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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