parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.07 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in rod photoreceptor cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 3621

receipt 3629: EML1 in dopamine neurons, braak

power: full sample -0.19 (p 0.455, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.17 (p 0.493, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.277, n 18). could be the mix.
skeptic: leave-one-out range -0.30 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.455, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for EML1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3628: EML1 in microglia, braak

power: full sample -0.09 (p 0.709, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.04 (p 0.861, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.02 (p 0.928, n 18). could be the mix.
skeptic: leave-one-out range -0.26 to -0.01, sign flips 0; without severely affected donors -0.09 (p 0.709, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for EML1 in microglia.

case closed: nothing better to follow up.

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