Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.06 (overall 0.03) | 0.06 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 7 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6407
Sealed predictions
- EIF3M in dopamine neurons, braak+0.58 (p 0.103) → +0.29 (p 0.443)receipt 6414
Swarm cases
receipt 6414: EIF3M in dopamine neurons, braak
- power
- full sample +0.41 (p 0.087, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.087, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.087, n 18). could be the mix.
- skeptic
- leave-one-out range +0.34 to +0.53, sign flips 0; without severely affected donors +0.41 (p 0.087, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for EIF3M in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts