parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in bergmann glia	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 94	0.85
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 5280

receipt 5289: DTNA in dopamine neurons, braak

power: full sample -0.06 (p 0.820, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.05 (p 0.847, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.03, sign flips 5; without severely affected donors -0.06 (p 0.820, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DTNA in dopamine neurons.

case closed: nothing better to follow up.

receipt 5288: DTNA in astrocytes, braak

power: full sample -0.00 (p 0.997, n 18), 95% CI -0.47 to +0.47. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.976, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.08 (p 0.767, n 18). could be the mix.
skeptic: leave-one-out range -0.13 to +0.12, sign flips 8; without severely affected donors -0.00 (p 0.997, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DTNA in astrocytes.

case closed: nothing better to follow up.

loading the receipts