parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.04 (overall 0.02)	0.04
cell type Human Protein Atlas	group enriched, including astrocytes; strongest in ependymal cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 139	0.85
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 7295

receipt 7304: DPP10 in dopamine neurons, braak

power: full sample +0.27 (p 0.285, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.29 (p 0.246, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.164, n 18). could be the mix.
skeptic: leave-one-out range +0.18 to +0.45, sign flips 0; without severely affected donors +0.27 (p 0.285, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DPP10 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7303: DPP10 in astrocytes, braak

power: full sample +0.05 (p 0.847, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.05 (p 0.847, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.02 (p 0.928, n 18). could be the mix.
skeptic: leave-one-out range -0.04 to +0.20, sign flips 3; without severely affected donors +0.05 (p 0.847, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DPP10 in astrocytes.

case closed: nothing better to follow up.

loading the receipts