Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.18 (overall 0.13) | 0.18 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 19 Parkinson's papers of 338 | 0.61 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2240
Sealed predictions
- DNM1L in dopamine neurons, braak-0.06 (p 0.879) → -0.46 (p 0.212)receipt 2247
Swarm cases
receipt 2247: DNM1L in dopamine neurons, braak
- power
- full sample -0.17 (p 0.504, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.14 (p 0.573, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.10 (p 0.702, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.06, sign flips 0; without severely affected donors -0.17 (p 0.504, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DNM1L in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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