Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 11 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4060
Sealed predictions
- DNAJC11 in dopamine neurons, braak-0.06 (p 0.873) → +0.00 (p 1.000)receipt 4067
Swarm cases
receipt 4067: DNAJC11 in dopamine neurons, braak
- power
- full sample -0.01 (p 0.983, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.956, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
- skeptic
- leave-one-out range -0.11 to +0.12, sign flips 8; without severely affected donors -0.01 (p 0.983, n 18). fragile.
- cell type
- strongest in microglia: -0.59 (p 0.0096, n 18) vs -0.01 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DNAJC11 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DNAJC11 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.68 p 0.016 (needs p < 4.9e-4)
Receipts
loading the receipts