parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.09 (overall 0.08)	0.09
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in cardiomyocytes	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	14 Parkinson's papers of 1,056	0.64
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 3146

receipt 3152: DISC1 in dopamine neurons, braak

power: full sample -0.04 (p 0.861, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.06 (p 0.814, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.834, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.08, sign flips 4; without severely affected donors -0.04 (p 0.861, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DISC1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3151: DISC1 in microglia, braak

power: full sample +0.08 (p 0.754, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.13 (p 0.615, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.11 (p 0.652, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.22, sign flips 1; without severely affected donors +0.08 (p 0.754, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DISC1 in microglia.

case closed: nothing better to follow up.

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