Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

DICER1

dicer 1, ribonuclease III

translation score 0.49, read 2026-10-19; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.08 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in neutrophils0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		4 Parkinson's papers of 1,6970.79
pathways
Reactome		5 pathways; mostly protein handling0.90

No case: the score is under the bar. Receipt 3218

Sealed predictions

  1. DICER1 in dopamine neurons, braak+0.11 (p 0.775) → +0.25 (p 0.508)receipt 3226
  2. DICER1 in oligodendrocytes, braak-0.06 (p 0.877) → +0.87 (p 0.002)receipt 3225

Swarm cases

receipt 3226: DICER1 in dopamine neurons, braak

power
full sample +0.11 (p 0.652, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.06 (p 0.807, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.12 (p 0.640, n 18). could be the mix.
skeptic
leave-one-out range -0.01 to +0.23, sign flips 2; without severely affected donors +0.11 (p 0.652, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DICER1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3225: DICER1 in oligodendrocytes, braak

power
full sample +0.43 (p 0.075, n 18), 95% CI -0.05 to +0.75. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.43 (p 0.072, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.67 (p 0.0022, n 18). not the mix.
skeptic
leave-one-out range +0.35 to +0.58, sign flips 0; without severely affected donors +0.43 (p 0.075, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DICER1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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