parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.09 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in late spermatids	0.75
chemistry Open Targets	a small-molecule pocket	0.50
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 3088

receipt 3096: DHRS1 in dopamine neurons, braak

power: full sample -0.44 (p 0.064, n 18), 95% CI -0.75 to +0.03. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.46 (p 0.057, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.050, n 18). not the mix.
skeptic: leave-one-out range -0.60 to -0.37, sign flips 0; without severely affected donors -0.44 (p 0.064, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DHRS1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3095: DHRS1 in oligodendrocytes, braak

power: full sample +0.04 (p 0.861, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.03 (p 0.894, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.08 (p 0.761, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.19, sign flips 5; without severely affected donors +0.04 (p 0.861, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DHRS1 in oligodendrocytes.

case closed: nothing better to follow up.

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