Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

DENND2B

DENN domain containing 2B

translation score 0.54, read 2026-10-27; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
reachable by antibody0.45
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly vesicle traffic1.00

No case: the score is under the bar. Receipt 11768

Sealed predictions

  1. DENND2B in dopamine neurons, braakn/a → n/areceipt 11775

Swarm cases

receipt 11775: DENND2B in dopamine neurons, braak

cell type
DENND2B is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DENND2B in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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