Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

DENND11

DENN domain containing 11

translation score 0.45, read 2026-10-29; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced in microglia (185 nCPM)1.00
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 14000

Sealed predictions

  1. DENND11 in microglia, braakn/a → n/areceipt 14006
  2. DENND11 in dopamine neurons, braakn/a → n/areceipt 14007

Swarm cases

receipt 14007: DENND11 in dopamine neurons, braak

cell type
DENND11 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DENND11 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14006: DENND11 in microglia, braak

cell type
DENND11 is not measured in microglia; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DENND11 in microglia.

case closed: nothing better to follow up.

Receipts

loading the receipts