Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 308 | 0.91 |
| pathways Reactome | 2 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 6567
Sealed predictions
- DEGS1 in dopamine neurons, braak+0.75 (p 0.019) → +0.03 (p 0.939)receipt 6574
Swarm cases
receipt 6574: DEGS1 in dopamine neurons, braak
- power
- full sample +0.57 (p 0.014, n 18), 95% CI +0.14 to +0.82. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.57 (p 0.014, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.58 (p 0.011, n 18). not the mix.
- skeptic
- leave-one-out range +0.50 to +0.65, sign flips 0; without severely affected donors +0.57 (p 0.014, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DEGS1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts