Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.13 (overall 0.08) | 0.13 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 56 | 0.82 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3261
Sealed predictions
- DDRGK1 in dopamine neurons, braak-0.16 (p 0.680) → +0.58 (p 0.103)receipt 3267
Swarm cases
receipt 3267: DDRGK1 in dopamine neurons, braak
- power
- full sample +0.02 (p 0.935, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.02 (p 0.949, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.787, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.10, sign flips 5; without severely affected donors +0.02 (p 0.935, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DDRGK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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