parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in hepatic stellate cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 398	0.85
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 8568

receipt 8577: DDAH1 in dopamine neurons, braak

power: full sample +0.31 (p 0.211, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.37 (p 0.135, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.37 (p 0.135, n 18). could be the mix.
skeptic: leave-one-out range +0.21 to +0.38, sign flips 0; without severely affected donors +0.31 (p 0.211, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DDAH1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 8576: DDAH1 in astrocytes, braak

power: full sample -0.13 (p 0.603, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.13 (p 0.603, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic: leave-one-out range -0.27 to -0.03, sign flips 0; without severely affected donors -0.13 (p 0.603, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DDAH1 in astrocytes.

case closed: nothing better to follow up.

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