Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 49 Parkinson's papers of 6,815 | 0.48 |
| pathways Reactome | 7 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 2895
Sealed predictions
- CYP1A2 in dopamine neurons, braak-0.42 (p 0.262) → -0.42 (p 0.266)receipt 2902
Swarm cases
receipt 2902: CYP1A2 in dopamine neurons, braak
- power
- full sample -0.39 (p 0.107, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.32 (p 0.194, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.060, n 18). could be the mix.
- skeptic
- leave-one-out range -0.47 to -0.32, sign flips 0; without severely affected donors -0.39 (p 0.107, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CYP1A2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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