Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.16 (overall 0.10) | 0.16 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 968 | 0.71 |
| pathways Reactome | 6 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2563
Sealed predictions
- CYLD in dopamine neurons, braak+0.17 (p 0.668) → -0.11 (p 0.787)receipt 2570
Swarm cases
receipt 2570: CYLD in dopamine neurons, braak
- power
- full sample -0.12 (p 0.627, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.487, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.04 (p 0.874, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to +0.01, sign flips 1; without severely affected donors -0.12 (p 0.627, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CYLD in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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