Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 312 | 0.85 |
| pathways Reactome | 10 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 6074
Sealed predictions
- CUL4B in dopamine neurons, braak+0.53 (p 0.145) → +0.60 (p 0.089)receipt 6081
Swarm cases
receipt 6081: CUL4B in dopamine neurons, braak
- power
- full sample +0.58 (p 0.011, n 18), 95% CI +0.16 to +0.82. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.56 (p 0.015, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.046, n 18). not the mix.
- skeptic
- leave-one-out range +0.52 to +0.71, sign flips 0; without severely affected donors +0.58 (p 0.011, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CUL4B in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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