parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in ocular epithelial cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 12526

CPAMD8 in astrocytes, braak-0.19 (p 0.631) → +0.57 (p 0.109)receipt 12533
CPAMD8 in dopamine neurons, braak+0.08 (p 0.838) → +0.03 (p 0.944)receipt 12534

receipt 12534: CPAMD8 in dopamine neurons, braak

power: full sample +0.06 (p 0.807, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.07 (p 0.774, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.00 (p 0.990, n 18). could be the mix.
skeptic: leave-one-out range -0.08 to +0.17, sign flips 2; without severely affected donors +0.06 (p 0.807, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CPAMD8 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12533: CPAMD8 in astrocytes, braak

power: full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.498, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.11 (p 0.671, n 18). could be the mix.
skeptic: leave-one-out range +0.08 to +0.31, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CPAMD8 in astrocytes.

case closed: nothing better to follow up.

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