Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 59 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4657
Sealed predictions
- COQ8A in dopamine neurons, braak-0.43 (p 0.244) → -0.32 (p 0.400)receipt 4665
Swarm cases
receipt 4665: COQ8A in dopamine neurons, braak
- power
- full sample -0.45 (p 0.062, n 18), 95% CI -0.76 to +0.02. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.42 (p 0.080, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.047, n 18). not the mix.
- skeptic
- leave-one-out range -0.58 to -0.38, sign flips 0; without severely affected donors -0.45 (p 0.062, n 18). robust.
- cell type
- strongest in oligodendrocytes: -0.65 (p 0.0037, n 18) vs -0.45 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COQ8A in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up COQ8A · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.13 p 0.657 (needs p < 4.2e-4)
Receipts
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