Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody: collagenase clostridium histolyticum, ocriplasmin | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 1,109 | 0.79 |
| pathways Reactome | 15 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 12450
Sealed predictions
- COL4A1 in dopamine neurons, braak+0.27 (p 0.474) → -0.72 (p 0.028)receipt 12458
Swarm cases
receipt 12458: COL4A1 in dopamine neurons, braak
- power
- full sample -0.32 (p 0.201, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.164, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.050, n 18). not the mix.
- skeptic
- leave-one-out range -0.45 to -0.24, sign flips 0; without severely affected donors -0.32 (p 0.201, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COL4A1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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