Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CNTNAP4

contactin associated protein family member 4

translation score 0.41, read 2026-10-19; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.10 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in early spermatids0.75
chemistry
Open Targets		reachable by antibody0.36
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		4 Parkinson's papers of 390.79
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 2729

Sealed predictions

  1. CNTNAP4 in dopamine neurons, braak+0.41 (p 0.272) → +0.19 (p 0.631)receipt 2737
  2. CNTNAP4 in oligodendrocytes, braak-0.01 (p 0.982) → -0.19 (p 0.619)receipt 2736

Swarm cases

receipt 2737: CNTNAP4 in dopamine neurons, braak

power
full sample +0.21 (p 0.403, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.21 (p 0.403, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.214, n 18). could be the mix.
skeptic
leave-one-out range +0.11 to +0.33, sign flips 0; without severely affected donors +0.21 (p 0.403, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CNTNAP4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2736: CNTNAP4 in oligodendrocytes, braak

power
full sample +0.08 (p 0.754, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.05 (p 0.854, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.16 (p 0.526, n 18). could be the mix.
skeptic
leave-one-out range -0.02 to +0.24, sign flips 3; without severely affected donors +0.08 (p 0.754, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CNTNAP4 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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