Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 124 | 0.76 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 9651
Sealed predictions
- CNTN4 in dopamine neurons, braak+0.42 (p 0.258) → +0.78 (p 0.013)receipt 9658
Swarm cases
receipt 9658: CNTN4 in dopamine neurons, braak
- power
- full sample +0.72 (p 8.2e-4, n 18), 95% CI +0.38 to +0.89. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.73 (p 6.2e-4, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.72 (p 8.2e-4, n 18). not the mix.
- skeptic
- leave-one-out range +0.68 to +0.77, sign flips 0; without severely affected donors +0.72 (p 8.2e-4, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CNTN4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts