Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CNPY1

canopy FGF signaling regulator 1

translation score 0.42, read 2026-10-29; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
enriched in the midbrain (9 nTPM), where the nigral dopamine neurons sit0.90
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 150.91
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 14368

Sealed predictions

  1. CNPY1 in dopamine neurons, braakn/a → n/areceipt 14376

Swarm cases

receipt 14376: CNPY1 in dopamine neurons, braak

cell type
CNPY1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CNPY1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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