Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.12 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 63 Parkinson's trials, 5 stopped | 0.92 |
| literature PubMed | 442 Parkinson's papers of 45,377 | 0.20 |
| pathways Reactome | 9 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 2334
Sealed predictions
- CLOCK in dopamine neurons, braak-0.20 (p 0.597) → +0.42 (p 0.266)receipt 2341
Swarm cases
receipt 2341: CLOCK in dopamine neurons, braak
- power
- full sample +0.05 (p 0.834, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.741, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.794, n 18). could be the mix.
- skeptic
- leave-one-out range -0.06 to +0.19, sign flips 3; without severely affected donors +0.05 (p 0.834, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CLOCK in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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