parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (6 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	7 Parkinson's papers of 244	0.73
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 8129

receipt 8136: CLN5 in dopamine neurons, braak

power: full sample +0.44 (p 0.066, n 18), 95% CI -0.03 to +0.75. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.52 (p 0.027, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.027, n 18). not the mix.
skeptic: leave-one-out range +0.37 to +0.58, sign flips 0; without severely affected donors +0.44 (p 0.066, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CLN5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 8135: CLN5 in microglia, braak

power: full sample +0.23 (p 0.360, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.23 (p 0.365, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.27 (p 0.273, n 18). could be the mix.
skeptic: leave-one-out range +0.13 to +0.42, sign flips 0; without severely affected donors +0.23 (p 0.360, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CLN5 in microglia.

case closed: nothing better to follow up.

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