parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.07 (overall 0.04)	0.07
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in respiratory ciliated cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 5566

CLEC19A in dopamine neurons, braak+0.08 (p 0.840) → -0.63 (p 0.068)receipt 5574
CLEC19A in microglia, braak+0.35 (p 0.350) → -0.06 (p 0.869)receipt 5573

receipt 5574: CLEC19A in dopamine neurons, braak

power: full sample -0.24 (p 0.346, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.26 (p 0.306, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.125, n 18). could be the mix.
skeptic: leave-one-out range -0.38 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.346, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CLEC19A in dopamine neurons.

case closed: nothing better to follow up.

receipt 5573: CLEC19A in microglia, braak

power: full sample +0.25 (p 0.319, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.28 (p 0.261, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.23 (p 0.365, n 18). could be the mix.
skeptic: leave-one-out range +0.18 to +0.44, sign flips 0; without severely affected donors +0.25 (p 0.319, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CLEC19A in microglia.

case closed: nothing better to follow up.

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