Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (early spermatids) | 0.10 |
| chemistry Open Targets | compounds already reach it: mecamylamine, pentolinium, simpinicline +5 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 205 | 0.82 |
| pathways Reactome | 4 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 9440
Sealed predictions
- CHRNB4 in dopamine neurons, braak-0.37 (p 0.334) → +0.03 (p 0.947)receipt 9447
Swarm cases
receipt 9447: CHRNB4 in dopamine neurons, braak
- power
- full sample -0.15 (p 0.544, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.16 (p 0.521, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.319, n 18). could be the mix.
- skeptic
- leave-one-out range -0.30 to -0.05, sign flips 0; without severely affected donors -0.15 (p 0.544, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHRNB4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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