Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in bergmann glia | 0.75 |
| chemistry Open Targets | compounds already reach it: doxacurium, gallamine triethiodide, suxamethonium +18 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 69 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 8241
Sealed predictions
- CHRNB1 in dopamine neurons, braak-0.27 (p 0.484) → +0.16 (p 0.682)receipt 8249
- CHRNB1 in astrocytes, braak-0.49 (p 0.182) → -0.23 (p 0.560)receipt 8248
Swarm cases
receipt 8249: CHRNB1 in dopamine neurons, braak
- power
- full sample -0.10 (p 0.690, n 18), 95% CI -0.54 to +0.38. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.754, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.15 (p 0.555, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to -0.01, sign flips 0; without severely affected donors -0.10 (p 0.690, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHRNB1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 8248: CHRNB1 in astrocytes, braak
- power
- full sample -0.33 (p 0.185, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.35 (p 0.153, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.26 (p 0.298, n 18). could be the mix.
- skeptic
- leave-one-out range -0.47 to -0.26, sign flips 0; without severely affected donors -0.33 (p 0.185, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHRNB1 in astrocytes.
case closed: nothing better to follow up.
Receipts
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