Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (neuroendocrine cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 1 Parkinson's papers of 367 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6771
Sealed predictions
- CHGA in dopamine neurons, braak-0.15 (p 0.705) → -0.89 (p 0.001)receipt 6779
Swarm cases
receipt 6779: CHGA in dopamine neurons, braak
- power
- full sample -0.45 (p 0.063, n 18), 95% CI -0.76 to +0.03. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.46 (p 0.055, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.019, n 18). not the mix.
- skeptic
- leave-one-out range -0.55 to -0.37, sign flips 0; without severely affected donors -0.45 (p 0.063, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHGA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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