Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.35 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (syncytiotrophoblasts) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 42 Parkinson's papers of 7,145 | 0.51 |
| pathways Reactome | 8 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0893
Sealed predictions
- CGA in dopamine neurons, braak+0.60 (p 0.089) → +0.11 (p 0.784)receipt 0899
Swarm cases
receipt 0899: CGA in dopamine neurons, braak
- power
- full sample +0.42 (p 0.082, n 18), 95% CI -0.06 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.34 (p 0.170, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.42 (p 0.084, n 18). could be the mix.
- skeptic
- leave-one-out range +0.35 to +0.58, sign flips 0; without severely affected donors +0.42 (p 0.082, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CGA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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