parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in monocytes	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	28 Parkinson's papers of 3,825	0.56
pathways Reactome	6 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 8768

receipt 8775: CFP in dopamine neurons, braak

power: full sample -0.23 (p 0.365, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.22 (p 0.374, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.111, n 18). could be the mix.
skeptic: leave-one-out range -0.33 to -0.12, sign flips 0; without severely affected donors -0.23 (p 0.365, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CFP in dopamine neurons.

case closed: nothing better to follow up.

receipt 8774: CFP in astrocytes, braak

power: full sample -0.19 (p 0.460, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.15 (p 0.555, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.03 (p 0.894, n 18). could be the mix.
skeptic: leave-one-out range -0.31 to -0.06, sign flips 0; without severely affected donors -0.19 (p 0.460, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CFP in astrocytes.

case closed: nothing better to follow up.

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