Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CELSR2

cadherin EGF LAG seven-pass G-type receptor 2

translation score 0.44, read 2026-10-23; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.02 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in epididymal principal cells0.75
chemistry
Open Targets		reachable by antibody0.36
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 1690.91
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 7381

Sealed predictions

  1. CELSR2 in dopamine neurons, braak-0.38 (p 0.315) → +0.41 (p 0.276)receipt 7390
  2. CELSR2 in oligodendrocytes, braak-0.32 (p 0.400) → -0.09 (p 0.820)receipt 7389

Swarm cases

receipt 7390: CELSR2 in dopamine neurons, braak

power
full sample -0.05 (p 0.840, n 18), 95% CI -0.51 to +0.43. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.09 (p 0.715, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.761, n 18). could be the mix.
skeptic
leave-one-out range -0.20 to +0.01, sign flips 4; without severely affected donors -0.05 (p 0.840, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CELSR2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7389: CELSR2 in oligodendrocytes, braak

power
full sample -0.30 (p 0.228, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.30 (p 0.228, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.38 (p 0.123, n 18). could be the mix.
skeptic
leave-one-out range -0.45 to -0.22, sign flips 0; without severely affected donors -0.30 (p 0.228, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CELSR2 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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