Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | 10 Parkinson's trials, 1 stopped | 0.92 |
| literature PubMed | 33 Parkinson's papers of 4,139 | 0.54 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 12159
Sealed predictions
- CEL in dopamine neurons, braak-0.26 (p 0.499) → -0.21 (p 0.584)receipt 12166
Swarm cases
receipt 12166: CEL in dopamine neurons, braak
- power
- full sample -0.37 (p 0.127, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.33 (p 0.179, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.055, n 18). could be the mix.
- skeptic
- leave-one-out range -0.50 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.127, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CEL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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