Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.52 from other evidence | 0.00 |
| cell type Human Protein Atlas | Human Protein Atlas did not answer (Human Protein Atlas: The operation was aborted due to timeout) | 0.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 686 | 0.85 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0186
Sealed predictions
- CDKN1C in dopamine neurons, braak-0.17 (p 0.663) → +0.30 (p 0.428)receipt 0192
Swarm cases
receipt 0192: CDKN1C in dopamine neurons, braak
- power
- full sample +0.10 (p 0.690, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.735, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.579, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.24, sign flips 1; without severely affected donors +0.10 (p 0.690, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CDKN1C in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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