Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in bergmann glia | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 16095
Sealed predictions
- CDH10 in oligodendrocytes, braak-0.22 (p 0.570) → +0.16 (p 0.685)receipt 16103
- CDH10 in dopamine neurons, braak+0.60 (p 0.090) → +0.40 (p 0.292)receipt 16104
Swarm cases
receipt 16104: CDH10 in dopamine neurons, braak
- power
- full sample +0.46 (p 0.055, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.47 (p 0.049, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.044, n 18). not the mix.
- skeptic
- leave-one-out range +0.40 to +0.68, sign flips 0; without severely affected donors +0.46 (p 0.055, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CDH10 in dopamine neurons.
case closed: nothing better to follow up.
receipt 16103: CDH10 in oligodendrocytes, braak
- power
- full sample -0.08 (p 0.761, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.627, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.03 (p 0.908, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.05, sign flips 3; without severely affected donors -0.08 (p 0.761, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CDH10 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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