Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.33 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (papillary tip epithelial cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 1016
Sealed predictions
- CDC42EP5 in dopamine neurons, braak-0.24 (p 0.539) → -0.04 (p 0.924)receipt 1022
Swarm cases
receipt 1022: CDC42EP5 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.351, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.277, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.351, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CDC42EP5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts