Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.12 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in kupffer cells | 0.75 |
| chemistry Open Targets | compounds already reach it: trx-1, clenoliximab, semzuvolimab +5 | 0.90 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 368 Parkinson's papers of 202,418 | 0.22 |
| pathways Reactome | 13 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 2340
Sealed predictions
- CD4 in dopamine neurons, braak-0.50 (p 0.172) → +0.59 (p 0.098)receipt 2348
- CD4 in microglia, braak-0.09 (p 0.812) → -0.47 (p 0.207)receipt 2347
Swarm cases
receipt 2348: CD4 in dopamine neurons, braak
- power
- full sample -0.03 (p 0.894, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.02 (p 0.928, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.956, n 18). could be the mix.
- skeptic
- leave-one-out range -0.18 to +0.11, sign flips 6; without severely affected donors -0.03 (p 0.894, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD4 in dopamine neurons.
case closed: nothing better to follow up.
receipt 2347: CD4 in microglia, braak
- power
- full sample -0.23 (p 0.365, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.24 (p 0.341, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.11, sign flips 0; without severely affected donors -0.23 (p 0.365, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD4 in microglia.
case closed: nothing better to follow up.
Receipts
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