Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.37 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in kupffer cells | 0.75 |
| chemistry Open Targets | compounds already reach it: lintuzumab, gemtuzumab, oncolysin m +2 | 0.81 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 21 Parkinson's papers of 4,257 | 0.59 |
| pathways Reactome | 3 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 0762
Sealed predictions
- CD33 in dopamine neurons, braak-0.20 (p 0.597) → +0.26 (p 0.504)receipt 0770
- CD33 in microglia, braak-0.41 (p 0.273) → +0.16 (p 0.672)receipt 0769
Swarm cases
receipt 0770: CD33 in dopamine neurons, braak
- power
- full sample +0.07 (p 0.781, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.07 (p 0.781, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.597, n 18). could be the mix.
- skeptic
- leave-one-out range -0.03 to +0.18, sign flips 4; without severely affected donors +0.07 (p 0.781, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD33 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0769: CD33 in microglia, braak
- power
- full sample -0.11 (p 0.658, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.09 (p 0.735, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to +0.02, sign flips 2; without severely affected donors -0.11 (p 0.658, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD33 in microglia.
case closed: nothing better to follow up.
Receipts
loading the receipts