Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in kupffer cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12872
Sealed predictions
- CD302 in microglia, braak-0.12 (p 0.749) → +0.07 (p 0.859)receipt 12880
- CD302 in dopamine neurons, braakn/a → n/areceipt 12881
Swarm cases
receipt 12881: CD302 in dopamine neurons, braak
- cell type
- CD302 is not measured in dopamine neurons; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD302 in dopamine neurons.
case closed: nothing better to follow up.
receipt 12880: CD302 in microglia, braak
- power
- full sample +0.06 (p 0.827, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.02 (p 0.942, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.03 (p 0.901, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.19, sign flips 4; without severely affected donors +0.06 (p 0.827, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD302 in microglia.
case closed: nothing better to follow up.
Receipts
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