Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (hofbauer cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 190 | 0.71 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 2499
Sealed predictions
- CD200R1 in dopamine neurons, braak+0.80 (p 0.009) → +0.33 (p 0.387)receipt 2506
Swarm cases
receipt 2506: CD200R1 in dopamine neurons, braak
- power
- full sample +0.53 (p 0.025, n 18), 95% CI +0.08 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.47 (p 0.049, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.043, n 18). not the mix.
- skeptic
- leave-one-out range +0.46 to +0.69, sign flips 0; without severely affected donors +0.53 (p 0.025, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD200R1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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